How Collagen Strengthens Bone

OsteoPruTect contains choline-stabilized orthosilicic acid (ch-OSA®)—one of the most effective substances on the market for promoting the generation of collagen. This collagen catalyst links together single chains of amino acids to form collagen strands. The collagen strands create the core-post "binding sites" for calcium and other bone minerals. In addition to helping reduce wrinkles, the oral supplementation of ch-OSA has been studied in chicks, rats, calves and humans. [1,2,3,4]

In a 12-month, randomized, double-blind, placebo-controlled trial, (n=136 women; T score <1.5), a study group received 6mg of ch-OSA along with 1,000mg calcium and 800 IU vitamin D3, while another group received a placebo in addition to the same amounts of calcium and vitamin D3. Upon completion, the study group showed a 19% increase in serum procollagen type 1 N-terminal propeptide (PINP), the most sensitive bone formation marker, an overall positive trend for other bone formation markers (BAP, osteocalcin), and a 2.00% increase in BMD compared to the women taking only placebo, calcium and vitamin D3. Additionally, the ch-OSA group showed no adverse effects. [5]

An earlier study demonstrated that orthosilicic acid directly stimulates collagen type 1 synthesis in human osteoblast-like cells (bone-forming cells) and enhances osteoblastic differentiation. [6] Another OSA study demonstrated that the increase in collagen-responsible bone flexibility resulted in a greater resistance to physical stress. [7]

In addition to strengthening bones, ch-OSA and the collagen it helps generate helps prevent wrinkles. A nice side benefit, no?

OsteoPruTect Now Available
As part of the PruTect Series, OsteoPruTect is now available from PruTectRx.

References

1. Calomme M. et al. Effect of ch-OSA on bone density in chicks. Poster presentation at 29th European Symposium on Calcifi ed Tissues May 25-29, 2002.
2. Calomme M, et al. Effect of choline stabilized orthosilicic acid on bone density in ovariectomized rats. J Bone Miner Res, 2004 Oct; (19)(S1), S449 [PMID: 16604283]
3. Calomme M, et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. Calcif Tissue Int. 2006; 78(4):227-32 [PMID: 16604283]
4. Calomme M, et al. Supplementation of calves with stabilized orthosilicic acid. Biol Trace Elem Res. 1997 Feb; 56(2):153-65 [PMID: 9164661]
5. Spector TD, Calomme MR, et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskeletal Disorders 2008, June 11; 9:85 [PMID: 18547426]
6. Reffi tt DM, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone 2003 Feb; 32(2):127-35 [PMID: 12633784]
7. Jugdaohsingh R, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res. 2004 Feb; 19(2):297-307 [PMID: 14969400]